{"id":2124,"date":"2025-11-16T21:58:01","date_gmt":"2025-11-16T20:58:01","guid":{"rendered":"https:\/\/lapatteduloup.fr\/?p=2124"},"modified":"2025-11-18T21:47:14","modified_gmt":"2025-11-18T20:47:14","slug":"hyperuricosurie","status":"publish","type":"post","link":"https:\/\/lapatteduloup.fr\/index.php\/2025\/11\/16\/hyperuricosurie\/","title":{"rendered":"Hyperuricosurie"},"content":{"rendered":"\n<p>L\u2019<strong>hyperuricosurie <\/strong>ou <strong>hyperuric\u00e9mie <\/strong>(HUU en anglais) est une anomalie g\u00e9n\u00e9tique rare, mais cliniquement importante. Elle se traduit par une <strong>excr\u00e9tion excessive d\u2019acide urique dans les urines<\/strong>, ce qui peut favoriser la formation de calculs d\u2019urate, notamment dans la vessie ou les reins.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"960\" src=\"https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/11\/hyperuricosurie.jpg\" alt=\"\" class=\"wp-image-2140\" style=\"width:323px;height:auto\" srcset=\"https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/11\/hyperuricosurie.jpg 960w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/11\/hyperuricosurie-300x300.jpg 300w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/11\/hyperuricosurie-150x150.jpg 150w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/11\/hyperuricosurie-768x768.jpg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<p>Chez un chien normal, l&rsquo;acide urique est converti en allanto\u00efne avant d\u2019\u00eatre \u00e9limin\u00e9. Chez les chiens affect\u00e9s, cette conversion est alt\u00e9r\u00e9e : l\u2019acide urique s\u2019accumule dans le sang (<em>hyperuric\u00e9mie<\/em>) et dans les urines (<em>hyperuricosurie<\/em>), augmentant le risque de cristaux ou de calculs d\u2019urate.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">Le d\u00e9pistage<\/h1>\n\n\n\n<p>Sans d\u00e9pistage g\u00e9n\u00e9tique et avant l\u2019apparition des calculs, <strong>aucun signe<\/strong> ne peut \u00eatre \u00e9vident : un chien porteur ou homozygote peut rester asymptomatique pendant longtemps.<\/p>\n\n\n\n<p>Quand des calculs d\u2019urate se forment, les sympt\u00f4mes peuvent \u00eatre les suivants :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>difficult\u00e9 \u00e0 uriner<\/strong>, miction douloureuse<\/li>\n\n\n\n<li><strong>sang dans les urines<\/strong><\/li>\n\n\n\n<li><strong>urines fr\u00e9quentes<\/strong> ou <strong>incontinence urinaire<\/strong><\/li>\n\n\n\n<li>douleurs abdominales <\/li>\n\n\n\n<li>chez les m\u00e2les : risque d\u2019obstruction ur\u00e9trale (due aux calculs), qui peut devenir une urgence v\u00e9t\u00e9rinaire (grossesse de la vessie, vomissements&#8230;)<\/li>\n<\/ul>\n\n\n\n<p>Si votre chien montre l\u2019un de ces sympt\u00f4mes, consultez un v\u00e9t\u00e9rinaire.<\/p>\n\n\n\n<p>Le diagnostic repose sur :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>une <strong>analyse d\u2019urine<\/strong>, afin de rechercher des cristaux d\u2019urate, d&rsquo;observer le rapport acide urique \/ cr\u00e9atinine ainsi que le pH urinaire<\/li>\n\n\n\n<li>une <strong>imagerie <\/strong>(radiographie abdominale, \u00e9chographie, ou techniques de contraste), afin de d\u00e9tecter des calculs dans la vessie ou les reins<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Un test ADN simple \u00e0 r\u00e9aliser<\/h2>\n\n\n\n<p>Un test ADN fiable permet d\u2019identifier les reproducteurs \u00e0 risque, d\u2019adapter les accouplements pour pr\u00e9venir la naissance de chiots atteints et limiter la propagation de l&rsquo;hyperuricosurie dans la race.<br>Chaque <strong>g\u00e8ne SLC2A9 <\/strong>\u00e9tant constitu\u00e9 de deux all\u00e8les (l\u2019un provenant de la m\u00e8re, l\u2019autre du p\u00e8re), ces all\u00e8les, qu\u2019ils soient sains ou mut\u00e9s, peuvent \u00eatre transmis \u00e0 la descendance. Cette mutation est h\u00e9rit\u00e9e de mani\u00e8re <strong>autosomique r\u00e9cessive<\/strong>.<br>Les r\u00e9sultats du test se divisent en trois cat\u00e9gories :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>HUU\/<strong>HUU<\/strong> <\/strong>(homozygote pour la mutation) = <strong>ATTEINT<\/strong> : forte probabilit\u00e9 de d\u00e9velopper les sympt\u00f4mes de l&rsquo;hyperuricosurie et de transmettre le g\u00e8ne mut\u00e9 \u00e0 la descendance.<\/li>\n\n\n\n<li><strong>N\/<strong>HUU<\/strong><\/strong> (h\u00e9t\u00e9rozygote pour la mutation) = <strong>PORTEUR<\/strong> : aucun risque de d\u00e9velopper les sympt\u00f4mes, mais possibilit\u00e9 de transmettre le g\u00e8ne mut\u00e9 \u00e0 la descendance.<\/li>\n\n\n\n<li><strong><strong>N\/N<\/strong><\/strong> (homozygote pour le g\u00e8ne normal) = <strong>SAIN<\/strong> : aucun risque de d\u00e9velopper ou de transmettre l&rsquo;hyperuricosurie.<\/li>\n<\/ul>\n\n\n\n<p>Dans le cadre de la <strong>reproduction des Altdeutsche Shaferhunde<\/strong>, l\u2019UCFAS n&rsquo;impose pas qu\u2019un d\u00e9pistage soit effectu\u00e9. A l&rsquo;\u00e9levage <em>La Patte du Loup<\/em> nous r\u00e9alisons tout de m\u00eame un test ADN sur nos reproducteurs (<a href=\"https:\/\/antagene.com\/chien\/altdeutsche-schaferhunde\" title=\"Antag\u00e8ne \">Antag\u00e8ne <\/a>et <a href=\"https:\/\/shop.embarkvet.com\/products\/embark-for-breeders-dog-dna-test-kit\" title=\"\">Embark <\/a>proposent ce type de test) afin d&rsquo;identifier la mutation ou non du g\u00e8ne.<\/p>\n\n\n\n<p>Pour plus d\u2019informations, consulter la <a href=\"https:\/\/ucfas.fr\/index.php?page=reglementation,elevage\">r\u00e9glementation d\u2019\u00e9levage de l\u2019UCFAS<\/a>.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">La prise en charge et les traitements<\/h1>\n\n\n\n<h3 class=\"wp-block-heading\">Approche di\u00e9t\u00e9tique<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>R\u00e9gimes <strong>pauvres en purines<\/strong> : pour diminuer la production d\u2019acide urique. <\/li>\n\n\n\n<li>Augmentation de l\u2019<strong>apport en eau<\/strong> : pour diluer les urines et r\u00e9duire la saturation en urates. <\/li>\n\n\n\n<li>Alcalinisation de l\u2019urine : selon les cas, des ajustements peuvent \u00eatre faits pour modifier le pH.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">M\u00e9dicament, chirurgie<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Certains m\u00e9dicament (ex: Allopurinol) r\u00e9duisent la production d\u2019acide urique.<\/li>\n\n\n\n<li>Si des calculs sont d\u00e9j\u00e0 form\u00e9s, une extraction chirurgicale peut \u00eatre envisag\u00e9e. Apr\u00e8s le retrait, un suivi r\u00e9gulier est primordial pour limiter toute r\u00e9cidive.<\/li>\n<\/ul>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"races_touchees\">Quelles races sont les plus touch\u00e9es ?<\/h1>\n\n\n\n<p>Les <strong>Dalmatiens <\/strong>sont particuli\u00e8rement connus pour cette mutation.<\/p>\n\n\n\n<p>L\u2019<strong>Orthopedic Foundation for Animals<\/strong> (OFA) met \u00e0 disposition sur son site internet des statistiques de maladies par races, on y retrouve les chiffres pour le Berger Allemand, ce qui permet de se faire une id\u00e9e sur ceux de l\u2019Altdeutsche Shaferhunde.<br>Sur 348 bergers allemands \u00e9valu\u00e9s, <strong>100% sont sains<\/strong> (N\/N).<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69fc84668d327&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69fc84668d327\" class=\"wp-block-image aligncenter size-full is-resized wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"861\" height=\"752\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/11\/OFA-classement-HUU-1.png\" alt=\"\" class=\"wp-image-2156\" style=\"width:579px;height:auto\" srcset=\"https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/11\/OFA-classement-HUU-1.png 861w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/11\/OFA-classement-HUU-1-300x262.png 300w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/11\/OFA-classement-HUU-1-768x671.png 768w\" sizes=\"auto, (max-width: 861px) 100vw, 861px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Agrandir\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n<p>Une \u00e9tude de 2010 a mis en \u00e9vidence que <strong>1.75% des Bergers Allemands <\/strong>test\u00e9s avaient une mutation associ\u00e9e l&rsquo;hyperuricosurie, sur un \u00e9chantillon de 114 Bergers Allemands.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\ud83d\udc49 <em><strong>L\u2019hyperuricosurie est une maladie g\u00e9n\u00e9tique grave mais bien comprise : gr\u00e2ce aux avanc\u00e9es g\u00e9n\u00e9tiques, elle peut \u00eatre diagnostiqu\u00e9e chez le chien par un test ADN et prise en charge efficacement par des mesures di\u00e9t\u00e9tiques, m\u00e9dicamenteuses et un suivi v\u00e9t\u00e9rinaire r\u00e9gulier.<\/strong><\/em><\/p>\n<\/blockquote>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading\">Sources<\/h1>\n\n\n\n<p class=\"has-extra-small-font-size\">Antag\u00e8ne. (s.d.). <em>Hyperuricosurie<\/em>. <a href=\"https:\/\/antagene.com\/maladie\/hyperuricosurie\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/antagene.com\/maladie\/hyperuricosurie<\/a><br>Embark Veterinary Inc. (s.d.). <em>Hyperuricosuria and hyperuricemia (urolithiasis, HUU).<\/em> <a href=\"https:\/\/embarkvet.com\/products\/dog-health\/health-conditions\/hyperuricosuria-and-hyperuricemia-or-urolithiasis-huu\/\">https:\/\/embarkvet.com\/products\/dog-health\/health-conditions\/hyperuricosuria-and-hyperuricemia-or-urolithiasis-huu\/<\/a><br>Orthopedic Foundation for Animals. (s.d.). <em>Disease statistics by breed<\/em>. OFA. <a href=\"https:\/\/ofa.org\/diseases\/disease-statistics\/?utm_source=chatgpt.com\">https:\/\/ofa.org\/diseases\/disease-statistics\/<\/a><br>Cornell University College of Veterinary Medicine. (s.d.). <em>Hyperuricosuria and hyperuricemia or urolithiasis (HUU)<\/em>.  <a href=\"https:\/\/www.vet.cornell.edu\/departments-centers-and-institutes\/riney-canine-health-center\/canine-health-information\/hyperuricosuria-and-hyperuricemia-or-urolithiasis-huu\">https:\/\/www.vet.cornell.edu\/departments-centers-and-institutes\/riney-canine-health-center\/canine-health-information\/hyperuricosuria-and-hyperuricemia-or-urolithiasis-huu<\/a><br>Today\u2019s Veterinary Practice. (2023). <em>Nutritional Management of Genetic Hyperuricosuria: Case Report<\/em>. <a href=\"https:\/\/todaysveterinarypractice.com\/nutrition\/nutritional-management-of-genetic-hyperuricosuria-case-report\/\">https:\/\/todaysveterinarypractice.com\/nutrition\/nutritional-management-of-genetic-hyperuricosuria-case-report\/<\/a><br>Generatio.de. (s.d.). <em>Hyperuricosuria and Hyperuricemia (HUU Dog)<\/em>. <a href=\"https:\/\/generatio.de\/en\/guidance\/lexicon\/hyperuricosuria-and-hyperuricemia-huu-dog\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/generatio.de\/en\/guidance\/lexicon\/hyperuricosuria-and-hyperuricemia-huu-dog<\/a><\/p>\n\n\n\n<p class=\"has-extra-small-font-size\">Bannasch, D., Safra, N., Young, A., Karmi, N., Schaible, R. S., &amp; Ling, G. V. (2008). Mutations in the <strong>SLC2A9<\/strong> gene cause hyperuricosuria and hyperuricemia in the dog. <em>PLoS Genetics, 4<\/em>(11) <a href=\"https:\/\/doi.org\/10.1371\/journal.pgen.1000246\">https:\/\/doi.org\/10.1371\/journal.pgen.1000246<\/a><br>Karmi, N., Safra, N., Young, A., &amp; Bannasch, D. L. (2010). Validation of a urine test and characterization of the putative genetic mutation for hyperuricosuria in Bulldogs and Black Russian Terriers. <em>American Journal of Veterinary Research, 71<\/em>(11), 909\u2013914. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5551899\/\" title=\"\"><\/a><a href=\"https:\/\/doi.org\/10.2460\/ajvr.71.8.909\">https:\/\/doi.org\/10.2460\/ajvr.71.8.909<\/a><br>Charlet, K. (2004). Maladies h\u00e9r\u00e9ditaires \u2014 syst\u00e8me urinaire : calculs d\u2019acide urique \/ hyperuricosurie. <em>Th\u00e8se v\u00e9t\u00e9rinaire, \u00c9cole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort<\/em>. <a href=\"https:\/\/www.centrale-canine.fr\/sites\/default\/files\/inline-files\/417-Maladies-hereditaires_2004_Ken_Charlet.pdf\">https:\/\/www.centrale-canine.fr\/sites\/default\/files\/inline-files\/417-Maladies-hereditaires_2004_Ken_Charlet.pdf<\/a><br>Motteau-L\u00e9v\u00eaque, M. (2024). \u00c9tude de la pr\u00e9dictibilit\u00e9 des donn\u00e9es \u00e9pid\u00e9miologiques et radiographiques pour d\u00e9terminer la nature min\u00e9rale d\u2019un calcul urinaire chez le chien. <em>Th\u00e8se v\u00e9t\u00e9rinaire, \u00c9cole Nationale V\u00e9t\u00e9rinaire d\u2019Alfort<\/em>. <a href=\"https:\/\/dumas.ccsd.cnrs.fr\/dumas-04660638v1\">https:\/\/dumas.ccsd.cnrs.fr\/dumas-04660638v1<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>L\u2019hyperuricosurie ou hyperuric\u00e9mie (HUU en anglais) est une anomalie g\u00e9n\u00e9tique rare, mais cliniquement importante. Elle se traduit par une excr\u00e9tion excessive d\u2019acide urique dans les urines, ce qui peut favoriser la formation de calculs d\u2019urate, notamment dans la vessie ou les reins. Chez un chien normal, l&rsquo;acide urique est converti en allanto\u00efne avant d\u2019\u00eatre \u00e9limin\u00e9. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2140,"comment_status":"open","ping_status":"closed","sticky":false,"template":"post-no-sidebar","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[57],"tags":[],"class_list":["post-2124","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sante"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/posts\/2124","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/comments?post=2124"}],"version-history":[{"count":20,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/posts\/2124\/revisions"}],"predecessor-version":[{"id":2172,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/posts\/2124\/revisions\/2172"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/media\/2140"}],"wp:attachment":[{"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/media?parent=2124"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/categories?post=2124"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/tags?post=2124"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}