{"id":1893,"date":"2025-10-15T22:14:49","date_gmt":"2025-10-15T20:14:49","guid":{"rendered":"https:\/\/lapatteduloup.fr\/?p=1893"},"modified":"2025-11-24T09:45:04","modified_gmt":"2025-11-24T08:45:04","slug":"sensibilite-medicamenteuse-mdr1","status":"publish","type":"post","link":"https:\/\/lapatteduloup.fr\/index.php\/2025\/10\/15\/sensibilite-medicamenteuse-mdr1\/","title":{"rendered":"Sensibilit\u00e9 m\u00e9dicamenteuse MDR1"},"content":{"rendered":"\n<p>La mutation <strong>MDR1<\/strong> (Multi-Drug Resistance) correspond \u00e0 une anomalie g\u00e9n\u00e9tique qui rend certains chiens <strong>hypersensibles \u00e0 plusieurs m\u00e9dicaments courants<\/strong>. Chez les individus porteurs, une simple dose normale peut provoquer des <strong>effets secondaires graves<\/strong>, voire une <strong>intoxication<\/strong>.<\/p>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p><em>Conna\u00eetre le statut MDR1 de son chien peut \u00e9viter des accidents graves lors d\u2019un simple traitement antiparasitaire.<\/em><\/p>\n<\/blockquote>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"784\" height=\"784\" src=\"https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/sommaire-MDR1.jpg\" alt=\"\" class=\"wp-image-2013\" style=\"width:380px;height:auto\" srcset=\"https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/sommaire-MDR1.jpg 784w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/sommaire-MDR1-300x300.jpg 300w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/sommaire-MDR1-150x150.jpg 150w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/sommaire-MDR1-768x768.jpg 768w\" sizes=\"auto, (max-width: 784px) 100vw, 784px\" \/><\/figure>\n\n\n\n<p>En 1983, il a \u00e9t\u00e9 rapport\u00e9 une sensibilit\u00e9 inhabituelle \u00e0 l\u2019ivermectine chez les Colleys et plusieurs races apparent\u00e9es, des investigations ont ensuite \u00e9t\u00e9 r\u00e9alis\u00e9es au cours des ann\u00e9es suivantes.<br>Cette mutation a d\u2019abord \u00e9t\u00e9 d\u00e9couverte en 2001 chez le Colley sur une lign\u00e9e sensible \u00e0 l&rsquo;ivermectine, mais elle touche aujourd\u2019hui <strong>plusieurs races <\/strong>de bergers, notamment le <strong>Berger Allemand<\/strong>.<\/p>\n\n\n\n<p>Bien que le g\u00e8ne MDR1 se transmet selon un <strong>mode autosomal r\u00e9cessif<\/strong>, il se comporte comme une maladie dominante pour l&rsquo;expression de la maladie. C-\u00e0-d que <strong>les chiens h\u00e9t\u00e9rozygotes (N\/MDR1) d\u00e9velopperont les sympt\u00f4mes de la maladie en cas d&rsquo;intoxication<\/strong>, \u00e0 un degr\u00e9 diff\u00e9rent des homozygotes atteints.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\">   Le d\u00e9pistage<\/h1>\n\n\n\n<p>Il existe actuellement <strong>11 races de chiens<\/strong> reconnues comme pouvant pr\u00e9senter une <strong>mutation du g\u00e8ne MDR1<\/strong>, qui sont les suivantes :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Berger allemand<\/li>\n\n\n\n<li>Berger australien<\/li>\n\n\n\n<li>Berger blanc suisse<\/li>\n\n\n\n<li>Colley<\/li>\n\n\n\n<li>Border collie<\/li>\n\n\n\n<li>Berger anglais<\/li>\n\n\n\n<li>Whippet \u00e0 poils longs<\/li>\n\n\n\n<li>Mac Nab<\/li>\n\n\n\n<li>Berger anglais ancestral (Bobtail)<\/li>\n\n\n\n<li>Shetland<\/li>\n\n\n\n<li>L\u00e9vrier de soie<\/li>\n\n\n\n<li>W\u00e4ller<\/li>\n<\/ul>\n\n\n\n<p>La mutation a \u00e9galement \u00e9t\u00e9 <strong>d\u00e9tect\u00e9e chez les chiens crois\u00e9s <\/strong>avec les races pr\u00e9c\u00e9dentes.<\/p>\n\n\n\n<p>Les r\u00e9actions ont \u00e9t\u00e9 observ\u00e9es apr\u00e8s l\u2019utilisation de <strong>m\u00e9dicaments v\u00e9t\u00e9rinaires courants<\/strong> : antiparasitaires, antidiarrh\u00e9iques, traitements cardiaques, anticanc\u00e9reux ou tranquillisants.<br>Les sympt\u00f4mes observ\u00e9s peuvent \u00eatre une mydriase, une c\u00e9cit\u00e9, une ataxie, des tremblements, parfois un coma et un d\u00e9c\u00e8s.<\/p>\n\n\n\n<p>Plus r\u00e9cemment, en 2023, la mutation du g\u00e8ne MDR1 a \u00e9t\u00e9 trouv\u00e9e sur 2 chiens de la race Huntaway, sur un \u00e9chantillon de 189 chiens en Nouvelle-Z\u00e9lande.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mol\u00e9cules concern\u00e9es<\/h2>\n\n\n\n<p>Le tableau ci-dessous liste (de mani\u00e8re <strong>non exhaustive<\/strong>) les <strong>mol\u00e9cules concern\u00e9es par la MDR1<\/strong>, qui interf\u00e9rent avec la glycoprot\u00e9ine P (P-gp) entra\u00eenant une accumulation des substances dans le liquide c\u00e9phalorachidien, o\u00f9 elles peuvent \u00eatre \u00e0 l&rsquo;origine d&rsquo;une neurotoxicit\u00e9.<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"432\" height=\"1024\" src=\"https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/Sensibilite-MDR1-molecules-432x1024.jpg\" alt=\"\" class=\"wp-image-2202\" style=\"width:393px;height:auto\" srcset=\"https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/Sensibilite-MDR1-molecules-432x1024.jpg 432w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/Sensibilite-MDR1-molecules-127x300.jpg 127w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/Sensibilite-MDR1-molecules-648x1536.jpg 648w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/Sensibilite-MDR1-molecules.jpg 745w\" sizes=\"auto, (max-width: 432px) 100vw, 432px\" \/><\/figure>\n\n\n\n<p>On retrouve dans ce tableau des mol\u00e9cules pr\u00e9sentes par exemples dans des antiparasitaires (ivermectine), des antidouleurs ou encore dans des antidiarrh\u00e9iques (loperamide\/imodium).<\/p>\n\n\n\n<p>L\u2019<strong>\u00e2ge augmente encore le risque<\/strong>, les mol\u00e9cules interf\u00e9rant avec la P-gp sont moins bien \u00e9limin\u00e9es par les reins.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">   Un test ADN simple \u00e0 r\u00e9aliser<\/h2>\n\n\n\n<p>Un test ADN fiable permet d\u2019identifier les reproducteurs \u00e0 risque, d\u2019adapter les accouplements pour pr\u00e9venir la naissance de chiots atteints et limiter la propagation de la MDR1 dans la race.<br>Chaque <strong>g\u00e8ne MDR1<\/strong> \u00e9tant constitu\u00e9 de deux all\u00e8les (l\u2019un provenant de la m\u00e8re, l\u2019autre du p\u00e8re), ces all\u00e8les, qu\u2019ils soient sains ou mut\u00e9s, peuvent \u00eatre transmis \u00e0 la descendance.<br>Les r\u00e9sultats du test se divisent en trois cat\u00e9gories :<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>MDR1\/MDR <\/strong>(homozygote pour la mutation) = <strong>ATTEINT<\/strong> : Le chien pr\u00e9sente un <strong>risque fort d&rsquo;intoxication<\/strong> <strong>m\u00e9dicamenteuse<\/strong>, il d\u00e9veloppera les sympt\u00f4mes d&rsquo;intoxication m\u00e9dicamenteuse et transmettra les copies mut\u00e9es du g\u00e8ne \u00e0 100% de sa descendance.<\/li>\n\n\n\n<li><strong>N\/MDR1<\/strong> (h\u00e9t\u00e9rozygote pour la mutation) = <strong>PORTEUR<\/strong> : Le chien pr\u00e9sente un <strong>risque mod\u00e9r\u00e9 d&rsquo;intoxication<\/strong>, il transmettra la copie mut\u00e9e du g\u00e8ne \u00e0 50% de sa descendance.<\/li>\n\n\n\n<li><strong><strong>N\/N<\/strong><\/strong> (homozygote pour le g\u00e8ne normal) = <strong>SAIN<\/strong> : Le chien n&rsquo;est pas sensible au g\u00e8ne MDR1, il ne d\u00e9veloppera pas de sympt\u00f4mes d&rsquo;intoxication m\u00e9dicamenteuse et ne transmettra pas de g\u00e8ne d\u00e9fectueux \u00e0 sa descendance.<\/li>\n<\/ul>\n\n\n\n<p>Dans le cadre de la <strong>reproduction des Altdeutsche Shaferhunde<\/strong>, l\u2019UCFAS n&rsquo;impose pas qu\u2019un d\u00e9pistage soit effectu\u00e9. A l&rsquo;\u00e9levage <em>La Patte du Loup<\/em> nous r\u00e9alisons tout de m\u00eame un test ADN sur nos reproducteurs (<a href=\"https:\/\/antagene.com\/chien\/altdeutsche-schaferhunde\" title=\"Antag\u00e8ne \">Antag\u00e8ne <\/a>et <a href=\"https:\/\/shop.embarkvet.com\/products\/embark-for-breeders-dog-dna-test-kit\" title=\"\">Embark <\/a>proposent ce type de test) afin d&rsquo;identifier la mutation ou non du g\u00e8ne.<br>Pour plus d\u2019informations, consulter la <a href=\"https:\/\/ucfas.fr\/index.php?page=reglementation,elevage\">r\u00e9glementation d\u2019\u00e9levage de l\u2019UCFAS<\/a>.<br><\/p>\n\n\n\n<h1 class=\"wp-block-heading\">Des traitements inexistants<\/h1>\n\n\n\n<p>\u00c0 ce jour, <strong>aucun traitement de la sensibilit\u00e9 m\u00e9dicamenteuse MDR1 n\u2019existe<\/strong>. L&rsquo;action \u00ab\u00a0curative\u00a0\u00bb consiste \u00e0 \u00e9viter ou adapter les doses des substances potentiellement toxiques pour le chien, en concertation avec le v\u00e9t\u00e9rinaire.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"races_touchees\">Quelles races sont les plus touch\u00e9es ?<\/h1>\n\n\n\n<p>Les donn\u00e9es du laboratoire Antag\u00e8ne donnent une fr\u00e9quence <strong>&lt; 1% d&rsquo;Altdeutsche Shaferhunde porteurs <\/strong>(homozygotes mut\u00e9s ou h\u00e9t\u00e9rozygotes). <br>Ce pourcentage est \u00e0 comparer \u00e0 la fr\u00e9quence relev\u00e9e par Antag\u00e8ne chez le Berger allemand (4%), le Berger blanc suisse (26%), le Berger australien (52%), le Shetland (56%) et le Colley (82%).<\/p>\n\n\n\n<p>En Janvier 2024, le laboratoire Embark a publi\u00e9 des statistiques d&rsquo;apparitions de la sensibilit\u00e9 m\u00e9dicamenteuse MDR1 dans le panel de Bergers Allemands test\u00e9s, donnant <strong>98.6 %<\/strong> <strong>de chiens sains<\/strong>, <strong>1.3%<\/strong> <strong>porteurs<\/strong>, et <strong>moins de 0,1 %<\/strong> <strong>\u00e9taient atteints<\/strong>.<\/p>\n\n\n\n<p>L\u2019<strong>Orthopedic Foundation for Animals<\/strong> (OFA) met \u00e0 disposition sur son site internet des statistiques de maladies par races, on y retrouve les chiffres pour le Berger Allemand.<br>Sur 408 bergers allemands \u00e9valu\u00e9s, <strong>96.3% sont sains<\/strong> (N\/N), <strong>3.7% sont porteurs <\/strong>(N\/MDR1) et <strong>0% sont atteints <\/strong>(MDR1\/MDR1).<\/p>\n\n\n\n<figure data-wp-context=\"{&quot;imageId&quot;:&quot;69fc84968a99a&quot;}\" data-wp-interactive=\"core\/image\" data-wp-key=\"69fc84968a99a\" class=\"wp-block-image aligncenter size-full is-resized wp-lightbox-container\"><img loading=\"lazy\" decoding=\"async\" width=\"966\" height=\"471\" data-wp-class--hide=\"state.isContentHidden\" data-wp-class--show=\"state.isContentVisible\" data-wp-init=\"callbacks.setButtonStyles\" data-wp-on--click=\"actions.showLightbox\" data-wp-on--load=\"callbacks.setButtonStyles\" data-wp-on-window--resize=\"callbacks.setButtonStyles\" src=\"https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/MDR1-OFA-statistic.png\" alt=\"\" class=\"wp-image-1958\" style=\"width:539px;height:auto\" srcset=\"https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/MDR1-OFA-statistic.png 966w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/MDR1-OFA-statistic-300x146.png 300w, https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/MDR1-OFA-statistic-768x374.png 768w\" sizes=\"auto, (max-width: 966px) 100vw, 966px\" \/><button\n\t\t\tclass=\"lightbox-trigger\"\n\t\t\ttype=\"button\"\n\t\t\taria-haspopup=\"dialog\"\n\t\t\taria-label=\"Agrandir\"\n\t\t\tdata-wp-init=\"callbacks.initTriggerButton\"\n\t\t\tdata-wp-on--click=\"actions.showLightbox\"\n\t\t\tdata-wp-style--right=\"state.imageButtonRight\"\n\t\t\tdata-wp-style--top=\"state.imageButtonTop\"\n\t\t>\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"12\" height=\"12\" fill=\"none\" viewBox=\"0 0 12 12\">\n\t\t\t\t<path fill=\"#fff\" d=\"M2 0a2 2 0 0 0-2 2v2h1.5V2a.5.5 0 0 1 .5-.5h2V0H2Zm2 10.5H2a.5.5 0 0 1-.5-.5V8H0v2a2 2 0 0 0 2 2h2v-1.5ZM8 12v-1.5h2a.5.5 0 0 0 .5-.5V8H12v2a2 2 0 0 1-2 2H8Zm2-12a2 2 0 0 1 2 2v2h-1.5V2a.5.5 0 0 0-.5-.5H8V0h2Z\" \/>\n\t\t\t<\/svg>\n\t\t<\/button><\/figure>\n\n\n\n<blockquote class=\"wp-block-quote is-layout-flow wp-block-quote-is-layout-flow\">\n<p>\ud83d\udc49 <em><strong>La mutation MDR1 reste rare chez l\u2019Altdeutsche Sch\u00e4ferhund, mais la prudence et le d\u00e9pistage restent essentiels pour \u00e9viter des accidents \u00e9vitables.<\/strong><\/em><\/p>\n<\/blockquote>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h1 class=\"wp-block-heading\">Sources<\/h1>\n\n\n\n<p class=\"has-extra-small-font-size\">Antagene. (s.d.). <em>Altdeutsche Sch\u00e4ferhunde \u2013 Chien<\/em>. <a href=\"https:\/\/antagene.com\/chien\/altdeutsche-schaferhunde\">https:\/\/antagene.com\/chien\/altdeutsche-schaferhunde<\/a><br>Antagene. (s.d.). <em>Sensibilit\u00e9 m\u00e9dicamenteuse MDR1<\/em>. <a href=\"https:\/\/antagene.com\/produits\/sensibilite-medicamenteuse-mdr1\" title=\"\">https:\/\/antagene.com\/produits\/sensibilite-medicamenteuse-mdr1<\/a><br>Jourdain, R. (2025). A history of MDR1. <em>Collie Health Foundation<\/em>. <a href=\"https:\/\/www.colliehealth.org\/a-history-of-mdr1\/\" title=\"\">https:\/\/www.colliehealth.org\/a-history-of-mdr1\/<\/a><br>Collie-Online. (s.d.). <em>MDR1 chez le Colley<\/em>. <a href=\"https:\/\/www.collie-online.com\/colley\/mdr1\/\">https:\/\/www.collie-online.com\/colley\/mdr1\/<\/a><br>Embark Vet. (s.d.). <em>MDR1 Drug Sensitivity (condition) \u2013 Dog Health<\/em>. <a href=\"https:\/\/embarkvet.com\/products\/dog-health\/health-conditions\/mdr1-drug-sensitivity\/\">https:\/\/embarkvet.com\/products\/dog-health\/health-conditions\/mdr1-drug-sensitivity\/<\/a><br>Embark Veterinary (s.d.). G<em>enetic health testing for German Shepherd dogs<\/em>. <a href=\"https:\/\/embarkvet.com\/resources\/genetic-health-testing-for-german-shepherd-dogs\/\" title=\"\">https:\/\/embarkvet.com\/resources\/genetic-health-testing-for-german-shepherd-dogs\/<\/a><br>GEDAC<strong>.<\/strong> (2013). <em>II 1. Sensibilit\u00e9 m\u00e9dicamenteuse MDR1<\/em>. Dans <a href=\"https:\/\/lapatteduloup.fr\/wp-content\/uploads\/2025\/10\/XXVIIeme-journees-annuelles-du-GEDAC-medicaments-sensibilite-MDR1.pdf\" title=\"\"><em>XXVIIes Journ\u00e9es Annuelles du GEDAC : M\u00e9dicaments et Sensibilit\u00e9 M\u00e9dicamenteuse<\/em> (pp. 20\u201324).<\/a> <br>Orthopedic Foundation for Animals. (s.d.). <em>Multiple Drug Sensitivity (MDR1)<\/em>. Orthopedic Foundation for Animals. <a href=\"https:\/\/ofa.org\/multiple-drug-sensitivity\/\" title=\"\">https:\/\/ofa.org\/multiple-drug-sensitivity\/<\/a><br>Orthopedic Foundation for Animals. (s.d.). <em>Disease statistics by breed<\/em>. <a href=\"https:\/\/ofa.org\/diseases\/disease-statistics\/\" title=\"\">https:\/\/ofa.org\/diseases\/disease-statistics\/<\/a><br>UCFAS. (s.d.). <em>D\u00e9pistage, MDR<\/em>. <a href=\"https:\/\/www.ucfas.fr\/index.php?page=depistage,md\">https:\/\/www.ucfas.fr\/index.php?page=depistage,md<\/a><br>VetCompendium. (2010, 15 mai). <em>La sensibilit\u00e9 de certaines races canines \u00e0 l&rsquo;ivermectine serait due \u00e0 une mutation g\u00e9n\u00e9tique<\/em>. <a href=\"https:\/\/www.vetcompendium.be\/fr\/node\/5095\" title=\"\">https:\/\/www.vetcompendium.be\/fr\/node\/5095<\/a><br>Washington Animal Disease Diagnostics Laboratory. (s.d.). <em>MDR1 in dogs<\/em>. <a href=\"https:\/\/waddl.vetmed.wsu.edu\/mdr1-in-dogs\/\">https:\/\/waddl.vetmed.wsu.edu\/mdr1-in-dogs\/<\/a><\/p>\n\n\n\n<p class=\"has-extra-small-font-size\">Barbet, J. L., Snook, T., Gay, J. M., &amp; Mealey, K. L. (2009). ABCB1-1\u0394 (MDR1-1\u0394) genotype is associated with adverse reactions in dogs treated with milbemycin oxime for generalized demodicosis. <em>Veterinary Dermatology, 20<\/em>(2), 111\u2013114. <a href=\"https:\/\/doi.org\/10.1111\/j.1365-3164.2008.00725.x\" title=\"https:\/\/doi.org\/10.1111\/j.1365-3164.2008.00725.x\">https:\/\/doi.org\/10.1111\/j.1365-3164.2008.00725.x<\/a><br>Dekel, Y., Machluf, Y., Stoler, A., Aderet, A., Baumel, D., Kellerman, E., Plotsky, Y., Noked Partouche, O., Elhalal, G., Ben-Shlomo, I., &amp; Bercovich, D. (2017). Frequency of canine nt230(del4) MDR1 mutation in prone pure breeds, their crosses and mongrels in Israel\u2014insights from a worldwide comparative perspective. <em>BMC Veterinary Research, 13<\/em>, 333. <a href=\"https:\/\/doi.org\/10.1186\/s12917-017-1251-9\" title=\"\">https:\/\/doi.org\/10.1186\/s12917-017-1251-9<\/a><br>Dowling, P. (2006). Pharmacogenetics: It&rsquo;s not just about ivermectin in collies. <em>Canadian Veterinary Journal<\/em>, 47(12), 1165\u20131168. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1636591\/\" title=\"\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC1636591\/<\/a><br>Gedye, K., Poole-Crowe, E., Shepherd, M., Wilding, A., Parton, K., Lopez-Villalobos, N., &amp; Cave, N. (2023). Prevalence of the ABCB1-1\u0394 gene mutation in a sample of New Zealand Huntaway dogs. <em>New Zealand Veterinary Journal<\/em>, 71(1), 67\u201371. <a href=\"https:\/\/doi.org\/10.1080\/00480169.2023.2181238\" title=\"\">https:\/\/doi.org\/10.1080\/00480169.2023.2181238<\/a><br>Geyer, J., D\u00f6ring, B., Godoy, J. R., Leidolf, R., Moritz, A., &amp; Petzinger, E. (2005). Frequency of the nt230 (del4) MDR1 mutation in Collies and related dog breeds in Germany. <em>Journal of Veterinary Pharmacology and Therapeutics<\/em>, <em>28<\/em>(6), 545\u2013551. <a href=\"https:\/\/doi.org\/10.1111\/j.1365-2885.2005.00692.x\" title=\"\">https:\/\/doi.org\/10.1111\/j.1365-2885.2005.00692.x<\/a><br>Geyer, J., Klintzsch, S., Meerkamp, K., W\u00f6hlke, A., Distl, O., Moritz, A., &amp; Petzinger, E. (2007). Detection of the nt230(del4) MDR1 mutation in White Swiss Shepherd dogs: Case reports of doramectin toxicosis, breed predisposition, and microsatellite analysis. <em>Journal of Veterinary Pharmacology and Therapeutics<\/em>, <em>30<\/em>(5), 482\u2013485. <a href=\"https:\/\/doi.org\/10.1111\/j.1365-2885.2007.00885.x\" title=\"\">https:\/\/doi.org\/10.1111\/j.1365-2885.2007.00885.x<\/a><br>Gramer, I., Leidolf, R., D\u00f6ring, B., Klintzsch, S., Kr\u00e4mer, E.-M., Yalcin, E., Petzinger, E., &amp; Geyer, J. (2011). Breed distribution of the nt230(del4) MDR1 mutation in dogs. <em>The Veterinary Journal, 189<\/em>(1), 67\u201371. <a href=\"https:\/\/doi.org\/10.1016\/j.tvjl.2010.06.012\" title=\"\">https:\/\/doi.org\/10.1016\/j.tvjl.2010.06.012<\/a><br>Hopper, K., Aldrich J, Askins S. C. (2002). Ivermectin toxicity in 17 Collies. <em>Journal of Veterinary Internal Medicine<\/em>, 16(1), 89-94. <a href=\"https:\/\/doi.org\/10.1111\/j.1939-1676.2002.tb01611.x\" title=\"https:\/\/doi.org\/10.1111\/j.1939-1676.2002.tb01611.x\">https:\/\/doi.org\/10.1111\/j.1939-1676.2002.tb01611.x<\/a><br>Hugnet C. (2005) Pharmacog\u00e9n\u00e9tique v\u00e9t\u00e9rinaire : exemple de la mutation MDR1 chez le Colley. In: <em>Bulletin de l&rsquo;Acad\u00e9mie V\u00e9t\u00e9rinaire de France<\/em> tome 158 n\u00b01, pp. 67-70. <a href=\"https:\/\/doi.org\/10.4267\/2042\/47755\" title=\"\">https:\/\/doi.org\/10.4267\/2042\/47755<\/a><br>Hugnet, C., Bentjen, S. A., &amp; Mealey, K. L. (2004). Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of collies from France. <em>Journal of Veterinary Pharmacology and Therapeutics, 27<\/em>(4), 227-229. <a href=\"https:\/\/doi.org\/10.1111\/j.1365-2885.2004.00585.x\" title=\"\">https:\/\/doi.org\/10.1111\/j.1365-2885.2004.00585.x<\/a><br>Mealey, K. L., Bentjen, S. A., Gay, J. M., &amp; Cantor, G. H. (2001). Ivermectin sensitivity in Collies is associated with a deletion mutation of the mdr1 gene. <em>Pharmacogenetics and Genomics, 11<\/em>(8), 727-733. <a href=\"https:\/\/doi.org\/10.1097\/00008571-200111000-00012\">https:\/\/doi.org\/10.1097\/00008571-200111000-00012<\/a><br>Seward, R. L. (1983). Reactions in dogs given ivermectin. <em>Journal of the American Veterinary Medical Association<\/em>, 183(5), 493. <a href=\"https:\/\/doi.org\/10.2460\/javma.1983.183.05.493\" title=\"https:\/\/doi.org\/10.2460\/javma.1983.183.05.493\">https:\/\/doi.org\/10.2460\/javma.1983.183.05.493<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>La mutation MDR1 (Multi-Drug Resistance) correspond \u00e0 une anomalie g\u00e9n\u00e9tique qui rend certains chiens hypersensibles \u00e0 plusieurs m\u00e9dicaments courants. Chez les individus porteurs, une simple dose normale peut provoquer des effets secondaires graves, voire une intoxication. Conna\u00eetre le statut MDR1 de son chien peut \u00e9viter des accidents graves lors d\u2019un simple traitement antiparasitaire. En 1983, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2013,"comment_status":"open","ping_status":"closed","sticky":false,"template":"post-no-sidebar","format":"standard","meta":{"ngg_post_thumbnail":0,"footnotes":""},"categories":[57],"tags":[],"class_list":["post-1893","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sante"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/posts\/1893","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/comments?post=1893"}],"version-history":[{"count":60,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/posts\/1893\/revisions"}],"predecessor-version":[{"id":2204,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/posts\/1893\/revisions\/2204"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/media\/2013"}],"wp:attachment":[{"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/media?parent=1893"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/categories?post=1893"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lapatteduloup.fr\/index.php\/wp-json\/wp\/v2\/tags?post=1893"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}